Ibrutinib Capsule 140mg

Ibrutinib Capsule 140 mg is a targeted therapy used to treat certain types of blood cancers and a specific complication following stem cell transplants. It is a prescription medication, commonly sold under the brand name Imbruvica.

Key Information:

• Active Ingredient: Ibrutinib (140 mg).

• Drug Class: Ibrutinib is a type of cancer medicine known as a Bruton's tyrosine kinase (BTK) inhibitor. It works by blocking the action of BTK, a protein that is essential for the survival and growth of certain cancer cells. By inhibiting this protein, Ibrutinib helps to kill cancer cells and slow down the progression of the disease.

• Uses: Ibrutinib is used to treat several conditions, including:

  • Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL): This includes patients who have been previously treated or who have a specific genetic mutation called a 17p deletion.

  • Waldenström's Macroglobulinemia (WM): A rare type of non-Hodgkin's lymphoma.

  • Chronic Graft-Versus-Host Disease (cGVHD): A serious complication that can occur after an allogeneic stem cell transplant, when the donor's immune cells attack the patient's body.

• Note: Ibrutinib is not a chemotherapy drug. It works through a different mechanism by specifically targeting a protein involved in the cancer's growth pathway.

Dosage and Administration:

• Ibrutinib is taken orally, usually once daily with a glass of water, at the same time each day.

• The capsules should be swallowed whole. They should not be opened, crushed, or chewed.

• The dose and duration of treatment are determined by a physician based on the specific condition being treated and the patient's response to therapy.

• It is crucial to follow the doctor's instructions precisely and not to stop taking the medication without consulting a healthcare provider.

Common Side Effects:

• Diarrhea

• Fatigue or feeling tired

• Nausea

• Bruising and bleeding (e.g., nosebleeds)

• Musculoskeletal pain (e.g., muscle or joint pain)

• Rash

• Fever

• Headache

Serious Side Effects and Warnings:

• Bleeding Problems: Ibrutinib can increase the risk of bleeding, which can be serious and, in rare cases, fatal. This risk is higher if you are also taking blood-thinning medications.

• Infections: The medication can lower the number of certain blood cells, making you more susceptible to infections. Fatal and non-fatal infections have occurred. Report any signs of infection, such as fever or chills, to your doctor immediately.

• Heart Problems: Serious heart rhythm problems (like atrial fibrillation or flutter) and heart failure have been reported. These can be fatal, especially in patients with pre-existing heart conditions.

• High Blood Pressure: New or worsening high blood pressure can occur. Your blood pressure will be monitored regularly.

• Second Primary Malignancies: Other cancers, particularly skin cancers, have been reported in patients taking Ibrutinib.

• Liver Problems: Ibrutinib can, in rare instances, cause liver damage.

• Pregnancy and Contraception: Ibrutinib can cause harm to an unborn baby. Women of child-bearing potential should use effective contraception during treatment and for a period after stopping the medication.

• Drug Interactions: Ibrutinib interacts with many other medications, including certain antifungals, antibiotics, and heart medications. It is essential to inform your doctor of all medicines, vitamins, and herbal supplements you are taking.